Endocrine Abstracts

Introduction: Neuroendocrine tumors of the lung (BP-NETs) are fairly rare tumors with very heterogeneous behavior and molecular characteristics. They are very heterogeneous concerning their malignancy, ranging from slow proliferating carcinoids (typical (TC) and atypical carcinoids (ATC)) to very aggressive large cell neuroendocrine carcinomas (LCNEC) and small cell lung cancers (SCLC). For the highly proliferative BP-NETs, combined chemotherapy is the standard therapy option,...

Background: Pulmonary neuroendocrine neoplasms are heterogeneous in their clinical behavior and therapeutic options are still not satisfactory. The ‘crosstalk’ of different signaling pathways in NEN cells appears to be more complex as known already. PKI-587 is a highly potent novel dual inhibitor of PI3K and mTORC1/C2.Aim: Therefore, we assessed the effects of PKI-587 in different pulmonary NEN cell lines compared to the established mTORC1 inhi...

Leptin acts not only as an anorexigenic hormone but is also involved in the regulation of cell-mediated immunity. However, since the impact of leptin on NK cells is currently elusive, we investigated the body weight-dependent leptin effects on NK cells numbers and function.In a first set of experiments leptin and MADB106 tumor cells were injected intravenously in male lean and diet-induced obese Lewis and F344 rats. In a second set of experiments an i...

Objective: Gastroenteropancreatic neuroendocrine neoplasm (GEP-NENs) are rare and heterogeneous in their tumor biology. Therapeutic options to prevent growth and dissemination are still not satisfactory. As shown previously, survivin and aurora kinases (members of the mitotic chromosomal passenger complex) play a role in cell cycle progression; FOXM1 is a transcription factor that regulates G2/M progression and is associated with grading and metastasis in GEP-NENs. Aurora kina...